Head Of Global Manufacturing Science & Technology Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life-threatening diseases. Headquartered in Bridgewater, New Jersey, we are advancing the next generation of cell therapy through a portfolio of innovative technologies, including autologous, allogeneic, and in vivo cell therapy approaches. Our research spans chimeric antigen receptor T-cell (CAR-T), T-cell receptor (TCR-T), natural killer (NK) cell-based therapies, and other emerging platforms designed to transform the treatment of serious diseases. From our global network of research and development sites, we are committed to discovering and developing safe, effective, and cutting-edge therapies for patients worldwide. Legend Biotech entered into a global collaboration agreement with Johnson & Johnson to jointly develop and commercialize CARVYKTI (ciltacabtagene autoleucel; cilta-cel). Through this strategic partnership, we combine complementary expertise and capabilities to advance innovative immunotherapies for patients living with multiple myeloma. Legend Biotech is seeking a Head of Global Manufacturing Science & Technology as part of the Manufacturing Science & Technology team based in Bridgewater, NJ.
Role Overview:
The Head of Global Manufacturing Science & Technology (MSAT) is the enterprise technical leader responsible for ensuring the robustness, scalability, capability, and continuous improvement of manufacturing processes across the product lifecycle. The role establishes the global MSAT strategy and provides technical leadership from late-stage development and technology transfer through commercial manufacturing and lifecycle management. The Head of Global Manufacturing Science & Technology ensures that manufacturing processes are scientifically understood, technically capable, operationally robust, scalable, and continuously improved to support reliable supply, product quality, patient needs, and business growth. As the enterprise technical authority for manufacturing processes, the Head of Global Manufacturing Science & Technology drives process robustness, technology transfer, process validation, continued process verification, technical investigations, manufacturing optimization, and advanced manufacturing capabilities across the global network. The incumbent will be a member of the GMS Leadership Team.
Key Responsibilities:
Define and execute the global MSAT strategy and operating model aligned with business, portfolio, and manufacturing priorities.
Establish global technical standards, capabilities, and governance for manufacturing processes across internal and external sites.
Serve as the senior technical authority for process capability, robustness, scalability, and manufacturing performance.
Own the technical strategy for process characterization, validation, process capability, continued process verification, and process monitoring.
Drive consistency and systematic improvement of manufacturing processes to increase yield, reliability, capacity, throughput, consistency, and cost efficiency.
Provide technical leadership for manufacturing investigations, process deviations, and recurring performance issues.
Establish science- and data-based approaches to identify process risks and proactively improve manufacturing performance.
Provide MSAT leadership for technology transfer and manufacturing readiness from development into commercial operations.
Ensure effective transfer of process knowledge, control strategies, technical standards, and manufacturing capabilities into internal and external manufacturing networks.
Partner with CMC and R&D to ensure development programs are designed for commercial scalability, manufacturability, and process robustness.
Provide technical input to major manufacturing network, capacity, and commercialization decisions.
Own the MSAT strategy for the technical lifecycle of commercial products, including process improvements, scale-up/scale-out, site transfers, capacity expansion, and manufacturing optimization.
Identify and prioritize opportunities to improve quality, yield, throughput, cost, cycle time, and supply resilience.
Lead implementation of advanced process technologies, automation, modeling, analytics, and digital manufacturing capabilities.
Ensure manufacturing knowledge and process data are systematically leveraged to drive continuous improvement.
Provide technical leadership, support and governance for MSAT activities at internal sites, CMOs/CDMOs and other external manufacturing partners.
Ensure consistent technical standards, process understanding, technology transfer, and lifecycle management across the global manufacturing network.
Partner with Manufacturing leadership to resolve technical, process, and performance issues.
Establish the strategic roadmap for advanced manufacturing technologies, automation, digital manufacturing, process analytics, and data science.
Accelerate adoption of emerging technologies that improve manufacturing control, predictability, flexibility, and efficiency.
Promote the use of data-driven and predictive approaches to enhance process understanding and manufacturing performance.
Build and lead a high-performing global MSAT organization with the technical depth and capabilities required to support a growing pipeline and commercial portfolio.
Develop organizational capabilities, talent, succession, and technical leadership across the global manufacturing network.
Serve as a senior member of the Global Manufacturing & Supply Leadership Team, contributing to manufacturing strategy, investment decisions, portfolio priorities, and supply resilience.
Act as a trusted technical advisor to senior leadership on major manufacturing, technology, process, and investment decisions.
Represent the company with strategic partners, regulators, industry organizations, and external technical forums.
Requirements:
Advanced degree, preferably PhD in Chemical Engineering, Biological Sciences, Pharmaceutical Sciences, or related discipline.20+ years of progressive experience in MSAT, process development, manufacturing science, technical operations, or related biopharmaceutical functions, including significant global leadership experience. Proven global experience leading MSAT for commercial biopharmaceutical products, preferably including cell therapy, gene therapy, or other advanced modalities. Strong expertise in process characterization, validation, technology transfer, CPV, process optimization, manufacturing technology, and lifecycle management. Proven ability to lead complex technical decisions across R&D, CMC, Manufacturing, Quality, Regulatory, Engineering, and Supply Chain. Enterprise technical leadership with strong business judgment. Strong strategic thinking combined with technical depth. Executive presence and ability to influence across functions and organizational boundaries. Data-driven, scientifically rigorous, and highly pragmatic. Strong innovation and continuous improvement mindset. Develops people, builds capabilities, and creates a culture of technical excellence, accountability, and innovation.
