Scientist Position We are seeking a Scientist to join a growing process development team focused on viral vector purification and downstream process development. This position will play a critical role in designing, executing, troubleshooting, and optimizing purification workflows supporting lentiviral and other viral vector programs in a research and development environment. The ideal candidate will bring strong hands-on experience with AKTA chromatography systems, tangential flow filtration (TFF), and viral vector purification. This is a highly laboratory-focused role where candidates will be responsible for the entire purification workflow, from experimental planning and preparation through execution, data analysis, documentation, and material handoff. The team values scientific rigor, organization, preparation, and flawless execution over speed. Candidates from lab-scale process development environments will be most successful in this position.
Key Responsibilities:
Downstream Process Development Design, execute, and optimize downstream purification processes for viral vector programs.
Develop purification workflows to improve yield, purity, and process robustness.
Support bench-scale process development activities and early-stage manufacturing readiness.
Evaluate process performance and recommend improvements based on data and experimental observations.
Chromatography & Purification Independently operate AKTA chromatography systems to perform purification campaigns.
Execute chromatography methods and monitor chromatograms in real time.
Perform process troubleshooting and root cause investigations.
Interpret chromatography data and document results.
Support purification activities utilizing FPLC, UPLC, or related chromatography systems when applicable.
Tangential Flow Filtration (TFF) Operate TFF systems for concentration and buffer exchange activities.
Develop and optimize filtration processes.
Monitor and evaluate key process parameters during filtration operations.
Perform process documentation and data analysis following each run.
Laboratory Operations Prepare buffers, reagents, and materials required for purification workflows.
Support depth filtration and clarification operations.
Maintain accurate laboratory records, batch documentation, and experimental summaries.
Coordinate material storage, sample management, and QC handoffs.
Participate in troubleshooting studies and process investigations.
Operate safely within a BSL-2 laboratory environment.
Cross-Functional Collaboration Collaborate closely with analytical, QC, process development, and scientific teams.
Communicate findings, challenges, and recommendations effectively.
Participate in process transfer and scale-up discussions as programs advance.
