Pediatric Genetics & Metabolism Division Chief

The Opportunity: The Department of Pediatrics at the University of Texas Southwestern Medical Center (UT Southwestern) isconducting a national/international search for the next Chief for the Division of Pediatric Genetics and Metabolism. Apply (by clicking the relevant button) after checking through all the related job information below. UTSouthwestern is a leader in genetics research and the treatment of genetic disorders. Reporting to the Chair of theDepartment of Pediatrics, the Chief of Pediatric Genetics and Metabolism will be charged with delivering state-of-theartconsultation, evaluation, counseling and clinical care to children with inherited diseases as well as known orsuspected genetic conditions at Children's Medical Centers of Dallas and Plano and in partnership with the NICUs atUT Southwestern affiliated hospitals. The Chief will also be responsible for developing, scaling, and innovating the Division's research and education programs. The successful candidate will have the opportunity to envision andrealize the future growth of an outstanding Pediatric Genetics and Metabolism program, within the vibrant and growingUT Southwestern Medical Center and Children's Health, both routinely considered among the nation's finest. Our ClientThe Division of Pediatric Genetics and Metabolism The mission of the UT Southwestern Pediatric Genetics and Metabolism Division is to provide excellent evaluation, diagnosis and treatment of children with genetic disorders, including birth defects, malformation syndromes, genetically defined developmental delays, and inborn errors of metabolism, while advancing the field through researchand innovation, as well as enhancing the education of future physicians. The Division has six full-time faculty members who play a pivotal role in advancing the Division's clinical and scholarlyprograms focused on a wide variety of genetic conditions such as inborn errors of metabolism, newborn screening, lysosomal storage disorders, craniofacial malformation syndromes, and incontinentia pigmenti. Faculty provide consultservices and outpatient care at Children's Health and support the NICUs at Parkland Health and University Hospital. Patient CareWith a large and growing team of physicians, genetic counselors, nurse practitioners, dieticians, and social workers, the Division is a major regional resource for children and families with genetic diseases. The team evaluates morethan 250 patients each month with known or suspected genetic diseases. Particular strengths of the clinical programinclude: The largest regional practice specializing in the diagnosis and treatment of children with inborn errors ofmetabolism 24/7 coverage for patients, with an M.D.Medical Geneticist on call at all times Several clinics specializing in malformation syndromes and genetic forms of developmental delay Expertise in the use and interpretation of advanced genetic diagnostics, including tests involving nextgeneration sequencing The only clinic in Dallas, and currently the only one in North Texas, that accepts referrals from the Texas Department of Health's newborn screening program for biochemical disorders Participation in multidisciplinary clinics specializing in relatively common disorders such as Down syndrome and22q11.2 deletion syndrome Clinical activities of the Division are focused in the following areas: Metabolic Disease ClinicThe Metabolic Disease Clinic provides evaluation and testing for children with knownor suspected inborn errors of metabolism (IEMs).UT Southwestern/Children's Health is a regional center ofexcellence in these diseases, establishing the diagnosis in affected children, counseling and educating theirfamilies about these conditions, and optimizing therapy tailored to the needs of each child. Blood, urine, enzyme, and DNA analyses are performed for diagnosis. Patients with a confirmed diagnosis are then providedwith nutritional evaluation, genetic counseling, and psychosocial assessment as well as long-term care. The Metabolic Disease Clinic is closely associated with the Newborn Screening Clinic; the Division is a majorreferral center for the Texas Newborn Screening Program. This statewide program seeks to identify newbornbabies with any of 30 different treatable diseases, many of which are genetic/metabolic in nature. Genetics/Dysmorphology Clinic Children with conditions involving birth defects, developmental delay ordevelopmental disabilities, or other known or suspected genetic disorders receive evaluation and testing in the Genetics/Dysmorphology Clinic. Chromosomal and DNA analysis for diagnosis of genetic disease is provided, as well as psychosocial assessment, counseling, and comprehensive case management with referral tomedical specialists, community resources, and support groups. Family history analysis and risk counseling todiscuss reproductive options also are available through a team of board-certified genetic counselors. Down Syndrome Clinic Faculty and staff in this clinic have more than 50 collective years of experience incaring for children with Down Syndrome and provide comprehensive treatment for children and their families, including medical management, genetic counseling, physical, speech and motor development evaluation andrecommendations, psychosocial support, screening and referral for behavioral and psychiatric problems, andreferral to community agencies for educational intervention or therapies. Interdivisional and Interdepartmental Collaborations The Division is a key contributor to the Children's Craniofacial program, participating in weekly careconferences involving Plastic Surgery, Dentistry, Otolaryngology, Medical Genetics, Psychology, and variousancillary services such as speech therapy and social work. Faculty also attend the monthly FETALconferences, a patient report and management planning meeting run by the department of Obstetrics &Gynecology and including Neonatology, Pediatric Surgery, Diagnostic Imaging, and Medical Genetics. Faculty see adult patients as needed in the FETAL center and have joined the Stillbirth Committee, an organof the Obstetrics & Gynecology department that reviews all the Parkland Hospital stillbirths. The Division provides Medical Genetics service in an outpatient clinic in the Aston Center, an ambulatorycare clinic at UT Southwestern Medical Center, performing diagnostic evaluations and ongoing managementof adult patients with Mendelian genetic disorders. This clinic is administered by the department of Internal Medicine and the Eugene McDermott Center for Human Growth and Development. Research The clinical team is unique in that it is fully synchronized with a state-of-the-art research program in the Children'sResearch Institute (CRI), a joint venture between UT Southwestern and Children's Health. The Genetic and Metabolic Disease Program (GMDP) within the CRI is comprised of a team of scientists dedicated to identifying new geneticdiseases and developing new ways to treat children with genetic disorders. The program uses advanced technologiesto evaluate each patient's genetic and metabolic individuality. Laboratory-based approaches in cellular and molecularbiology are used to understand the precise consequences of the DNA mutations identified in patients. The researchteam is funded through federal, state, and private grant support. Specific research goals within the GMDP include efforts to: Discover new genetic causes of childhood diseases Understand the genetic basis of a range of metabolic functions and its relationship to health and disease in children Develop new diagnostic methods to detect genetic diseases in patients Establish clinical trials to assess the effect of new treatments Construct new disease models using genetically modified mice and use them to test the effect of experimental therapies Use multidisciplinary approaches to identify and characterize novel malformation syndromes. The Division has been involved in clinical research projects involving clinical trials of new therapies, as well asmulticenter studies in clinical and molecular genetics. The Division has been involved in translational research, helpingto make a bridge between the basic science researchers in molecular genetics and the patients. The DeBerardinis Lab uses a combination of techniques in molecular biology, cell biology, and biochemistry, coupled with metabolic flux analysis using mass spectrometry and nuclear magnetic resonance, and animalmodels of metabolism and cancer. Current projects include developing imaging probes to identify abnormalmetabolic activities in tumors and in children with metabolic diseases. Dr. Angela Scheuerle's work with the Texas Department of State Health Services Birth Defects Epidemiologyand Surveillance Branch (BDES) affords excellent opportunity for both care and research at the public healthlevel. In 2016, this became dramatically important in the state's preparation for the Zika virus. Dr. Scheuerleparticipated with others in the BDES to define case ascertainment parameters, expand information collectedabout cases with microcephaly, and provide fast-track surveillance for relevant cases. This work continues asthe state establishes a baseline for microcephaly incidence in anticipation of autochthonous Zika transmission. In 2021, the Division of Pediatric Genetics and Metabolism led an effort to have UT Southwestern and Children'sHealth designated as a Rare Disease Center of Excellence (COE) by the National Organization of Rare Disorders(NORD).NORD advocates for patients of all ages suffering from about 7,000 rare diseases, many of which havegenetic causes and manifest in childhood. UT Southwestern is among an inaugural group of 31 medical centersparticipating in this network. The COE is directed by faculty in the Division and involves over 30 physicians from sevenclinical departments. The COE designation recognizes UT Southwestern's long-standing excellence in both clinicalcare and research in rare disorders and attracts patients seeking advanced treatment for these diseases. UTSouthwestern faculty across departments are active in national level working groups within the COE network. Thedesignation also boosts efforts to recruit the best clinicians, researchers and trainees in medical genetics and relatedspecialties. The COE supports academic retreats focused on rare disease clinical care and research and campuswideeducational efforts in rare diseases. McDermott Center for Human Growth and Development The Division partners closely with the McDermott Center for Human Growth and Development, which serves as the Center for Human Genetics at UT Southwestern. The Center provides expertise and resources for clinicians and basicscientists to identify genes and sequence variations that contribute to human diseases and traits. Dr. RalphDeBerardinis, the prior Division Chief of Pediatric Genetics and Metabolism, is the Director of the McDermott Center. This sets the stage for even greater synergism between the Division and the McDermott Center. The McDermottCenter has several core facilities that provide specialized services, including: DNA Genotyping Core DNA Next Generation Sequencing Core DNA Sanger Sequencing Core Human Genetics Clinical LaboratoryUT Southwestern and the McDermott Center are planning a campus-wide initiative in population genomics, which willinvolve exome sequencing and deep phenotyping of at least 150,000 individuals of all ages in the Dallas area. Thispromises to be a rich source of data that will benefit all those pursuing genetics research, including the faculty andtrainees in the Division. Education The Division is a vital part of UT Southwestern Medical Center's mission to train medical students, residents, fellows, and allied health professionals in pediatrics, genetics, and metabolism. Faculty in the Division teach medical studentsand pediatric residents throughout their training, manage an accredited residency program to train the next generationof physicians in Medical Genetics, co-direct a fellowship program in Laboratory Genetics and Genomics, and providecontinuing medical education in genetics and metabolism to the Dallas-Fort Worth medical community. Medical Students First year medical school curriculum includes: Medical Biochemistry Course: protein and amino acid metabolism, hyperammonemia and urea cycle defects, defects in amino acid metabolism (PKU, MSUD, etc.), purine and pyrimidine metabolism, and treatment ofinborn errors of metabolism Medical Genetics Course: population genetics, inborn errors of metabolism, assessing genetic risk/pedigreeanalysis, genetic screening, genetic counseling, and ethical issues in genetics Third-year medical students participate in pediatrics rotations involving: Case studies in clinical genetics Genetics clinic outpatient rotations Clinical genetics consultations The Division offers an elective in clinical genetics to fourth-year medical students involving outpatient genetics clinicsand inpatient genetics consultations. Medical Genetics Interest GroupWe provide mentorship to UT Southwestern medical students considering a career in Medical Genetics. This highlysuccessful interest group meets periodically to discuss new developments in clinical and research-based genetics. Weseek to provide an environment to educate students about career opportunities in this exciting and rapidly expandingarea of pediatrics. Medical Genetics Residency Program The Department of Pediatrics, through the Division of Pediatric Genetics and Metabolism, sponsors the clinicaldepartment for the ACGME certified training program in Medical Genetics. Medical Genetics stands alone as aspecialty, rather than being a subspecialty of Pediatrics, Internal Medicine, or Obstetrics/Gynecology. The trainingprogram encompasses many clinical departments including Pediatrics, Internal Medicine, Obstetrics/Gynecology(prenatal diagnosis), Neurology and Pathology (Clinical Molecular Genetics, Cytogenetics, and Biochemical Genetics), among others. PediatricsThe Division provides didactic teaching for the pediatric residents, including: Clinical dysmorphology Cause and evaluation of birth defects Common chromosome anomalies Newborn screening Acute metabolic disorders Genetic storage disorders The Division offers a Clinical Genetics elective to second- and third-year pediatric residents. The residents seeoutpatients in the Division's clinic and inpatients for consultation services under the supervision of one of the membersof the Division's faculty. Residents are encouraged to participate in clinical research projects. Trainees in other departments also spend time in the Division's clinics. Residents in Neurology, Pathology, and otherspecialties may receive some of their training through the Division of Pediatric Genetics and Metabolism. Learn more about the Division here: Department of PediatricsThe Department of Pediatrics at UT Southwestern has a long and rich history that is interwoven with the roots of UTSouthwestern Medical School and with the development and growth of Children's Health, its primary clinical partnerwith leading inpatient care at Children's Medical Center in Dallas and Plano and multispecialty outpatient centers inDallas, Plano, Prosper and other health care units throughout the Dallas Metroplex. The Department is structured into17 academic divisions, consisting of greater than 415 faculty members and several clinical multidisciplinary programsto cover the full spectrum of child health and disease. Learn more about the department here: of Texas Southwestern Medical CenterUT Southwestern, one of the nation's premier academic medical centers, is located just a short drive from downtown Dallas. The campus integrates pioneering biomedical research with exceptional clinical care and education. Theinstitution's faculty number more than 2,800 and includes six who have been awarded Nobel Prizes since 1985, 25members of the National Academy of Sciences, 16 members of the National Academy of Medicine, and 13investigators in the Howard Hughes Medical Institute. UT Southwestern physicians provide medical care in about 80specialties to more than 117,000 hospitalized patients, nearly 360,000 emergency room cases, and overseeapproximately 3 million outpatient visits a year. Many are cared for in the three major hospitals on campus: Clements University Hospital, Parkland Memorial Hospital, and Children's Medical Center Dallas. In 2024, UT Southwestern was recognized as the #2 hospital in Texas and ranked nationally in all 11 specialty areasby U.S.News & World Report – one of only a few hospitals in the U.S.to earn that distinction. With a core emphasison advancing scientific discovery, UT Southwestern is also ranked among the top 25 medical school researchprograms in the nation by U.S.News & World Report. Last year, UTSW was awarded more than $290 million insupport from the NIH.Children's Medical Center Dallas (Children's Health) For more than 110 years, Children's Health has pursued a long-standing commitment to the community to providehigh-quality patient care, advocacy, and education with an unwavering focus on their mission: to make life better forchildren. Children's Health is hailed as one of the largest and most prestigious pediatric health care providers in thecountry. The institute is comprised of 8,400 employees, providing care for more than 288,000 patients annually. Through a longstanding academic affiliation with UT Southwestern, Children's Health serves as a leader in lifechangingtreatments, innovative technology and ground-breaking research. The institute is consistently recognizedamong the top children's hospitals in the country including its ranking by U.S.News & World Report as the toppediatric hospital in North Texas, number 2 in the Southwest, and number 13 in the nation for 2023-2024.Joint Pediatric Enterprise (JPE)UT Southwestern Medical Center is proud to collaborate with Children's Health to recruit top-caliber faculty andpediatric advanced practice providers who work within both health care systems to provide the very best care forchildren and their families. The Joint Pediatric Enterprise (JPE), formed in 2019, is structured to facilitate shared decision-making and operationalalignment between UT Southwestern and Children's Health, which have been affiliated for more than 60 years. Together, the institutes are better equipped to meet the rapidly growing needs of the North Texas pediatric communityand beyond. This powerful partnership strengthens patient outcomes by providing access to renowned faculty, biomedical research, and clinical trials. As part of the JPE, UT Southwestern Medical Center and Children's Health broke ground on October 1, 2024 ona new $5 billion pediatric health campus in Dallas' Southwestern Medical District. Spanning more than 33 acres, the new pediatric campus will encompass more than 4.7 million square feet of construction, including a new pediatrichospital as its centerpiece. The hospital, comprised of two 12-story towers and an 8-story tower, along with thebroader care site, will significantly expand inpatient, surgical, and ambulatory capacity to meet the needs of one of thefastest-growing and largest metropolitan areas in the country. As North Texas experiences unprecedented growth, and with the pediatric population expected to double by 2050, there is an urgent demand for advanced pediatric health care. To meet those needs, the new campus will expandaccess to a full range of pediatric services from routine care to complex treatments, creating a one-of-a-kind hub foracademic research, training, and the development of life-saving technologies. The pediatric campus, which willreplace the existing Children's Medical Center Dallas, is expected to open in the next six to seven years. It will be builton the UT Southwestern campus on the corner of Harry Hines Boulevard and Mockingbird Lane, across from UTSW'sWilliam P.Clements Jr. University Hospital. Highlights of the project include:

• 4.7 million square feet of construction
• 552 beds (38% increase) with space for future expansion
• Expanded Emergency Department space (15%) and operating rooms (22%)
• Two helicopter pads
• A Level I pediatric trauma center, 90 ER exam rooms, and 24 observation rooms
• A connector bridge between the new campus and Clements University Hospital, ensuringcontinuity of care for babies with direct access to the pediatric expertise provided at the Children's HealthLevel IV Neonatal Intensive Care Unit (NICU) and Cardiovascular Intensive Care Unit (CVICU)
• A new fetal care center to provide the region's most advanced and accessible services for complex maternaland fetal health care, including fetal surgery capabilities at the adjoining Clements University Hospital
• A new outpatient clinic building that will add 96 exam rooms to the 344 that will continue to operate at theexisting Children's Health Specialty Center Dallas outpatient facility on Stemmons Freeway at Medical District DriveThe new pediatric campus adds to the ongoing investments by UT Southwestern and Children's Health to meet theregion's growing pediatric medical and surgical needs.

In October 2024, the new Children's Health Plano hospitaltower opened and substantially increased the number of beds to increase access to care for children in North Texas. The partnership is also expanding access to care in surrounding communities with new specialty centers, a growingreferral network, and more – each a part of their commitment to growing with North Texas, anticipating long-termpediatric needs, and providing extraordinary care close to home. Milestone gifts from The Jean and Mack Pogue Family Foundation and the The Rees-Jones Foundation A recent $100 million gift from The Rees-Jones Foundation to support the construction of the new pediatric campusfollowed a $100 million gift from the Jean and Mack Pogue Family Foundation in May. This marks the first timein Texas that a not-for-profit construction project has received two individual leadership gifts of $100 million. At the October 1st groundbreaking ceremony, Troy Aikman and Dirk Nowitzki, both champion athletes and champions forchildren, joined in the historic gift announcement. To publicly recognize The Rees-Jones Foundation gift, the central hospital tower at the new Dallas pediatric campuswill be named Rees-Jones Tower. In addition, the greenspace on which the campus will reside will be known as the Pogue Family Park.

Nomination and Application Procedure To receive full consideration, interested individuals should electronically submit a Curriculum Vitae and a letter ofinterest to Russell Reynolds Associates. The letter of interest is a two-page cover letter, primarily detailing yourexperience, qualification, and key achievements related to this position specification and briefly expressing yourinterest in this Chief role. Applications will be reviewed immediately and accepted until the position is filled. Allinquiries should be sent to: Vuturo Russell Reynolds Associates155 North Wacker DriveSuite 4100 Chicago, IL 60606-1732 Mobile: Grover Russell Reynolds Associates155 North Wacker DriveSuite 4100 Chicago, IL 60606-1732 Mobile: Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. As an equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status. This position is security-sensitive and subject to Texas Education Code 51.215, which authorizes UT Southwestern to obtain criminal history record information. Appointment rank will be commensurate with academic accomplishment and experience. Consideration may be given to applicants seeking less than a full-time schedule. To learn more about the benefits UT Southwestern offers, visit BenefitsUT Southwestern is proud to offer a competitive and comprehensive benefits package to eligible employees. xhyhwjd Our benefits are designed to support your overall wellbeing, and include: PPO medical plan, available day one at no cost for full-time employee-only coverage 100% coverage for preventive healthcare – no copay Paid Time Off, available day one Retirement Programs through the Teacher Retirement System of Texas (TRS) Paid Parental Leave Benefit Wellness programs Tuition Reimbursement Public Service Loan Forgiveness (PSLF) Qualified Employer Learn more about these and other UTSW employee benefits!

Job Area: Faculty and Physicians Posted Date: 10/01/2025