Principal Clinical Scientist

About The Role: What if your career-long expertise in clinical trial design and regulatory science could directly shape how AI reasons about medical evidence - influencing the systems that will define the future of biomedical research? We're looking for a Principal Clinical Scientist to bring senior-level clinical rigor into the development of cutting-edge AI models. You'll work alongside world-leading AI research teams to ensure the clinical data, analyses, and reasoning embedded in frontier AI systems meet the standards expected in real-world regulatory submissions. This is a fully remote, flexible contract role built for experienced clinical scientists who want to do meaningful work on their own terms.

Organization: Alignerr

Type: Hourly Contract

Location: Remote

What You'll Do: Design and critically review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training and evaluation Interpret and audit clinical trial results to ensure accuracy, internal consistency, and alignment with regulatory standards Evaluate AI-generated clinical analyses for scientific soundness, methodological integrity, and regulatory relevance Provide expert, structured feedback that directly improves how AI models reason about clinical trial data, endpoints, and outcomes Help establish the bar for what rigorous, trustworthy clinical AI looks like in practice

Who You Are: Senior-level clinical scientist with hands-on experience designing trial protocols for regulatory submission (FDA, EMA, or equivalent) Deep expertise interpreting clinical data and navigating the expectations of major regulatory agencies Strong grounding in clinical research methodology, biostatistics, translational science, or a related discipline Meticulous and structured in how you evaluate evidence - you notice when something doesn't hold up Able to communicate complex scientific judgments clearly and concisely in written form Comfortable working independently and asynchronously in a remote environment

Nice to Have: Prior experience with data annotation, data quality frameworks, or AI evaluation workflows Background in pharmacovigilance, outcomes research, or health technology assessment Familiarity with AI tools or clinical informatics platforms

Why Join Us: Work directly on frontier AI systems that are reshaping how clinical and biomedical research is understood and conducted Influence how AI evaluates, interprets, and communicates real-world clinical evidence at scale Fully remote and flexible - work when and where it suits you, with no fixed schedule Freelance autonomy with meaningful, intellectually rigorous work on every projectCollaborate with leading AI research labs and clinical experts from around the world Potential for ongoing work and contract extension as new projects launch