Neomorph is seeking an experienced associate scientist with a passion for drug discovery and extensive experience with BSL2/2+ practices and routine molecular and cell biology techniques. The role will be critically involved in supporting Neomorph's internal pipeline through contributions to both target identification and validation efforts, as well as by enabling decision-making through the generation of robust data packages. The successful applicant will be an integral member of project teams and will be responsible for communicating broadly across the organization.
Key Responsibilities:
Profile the biological activities of lead compounds in relevant cellular models/assays. Assess glue degrader mechanism of action using established assays. Elucidate biological mechanisms of action that confer pharmacodynamic effects of lead compounds. Delineate mechanisms of sensitivity and resistance using chemical and genetic approaches to define desired compound profiles. Support molecular and cell biology platforms for target identification and validation through plasmid cloning and cell line engineering. Analyze and document experimental results using Microsoft Excel, GraphPad Prism, and other applicable data systems. Communicate results and solicit effective input and feedback in a variety of internal settings. Required
Qualifications:
MS with 5+ years, or BS with 8+ years of industry experience. Proficiency with routine cell and molecular biology techniques including tissue culture, immunofluorescence, qRT-PCR, western blotting, and ELISA. Proficiency with BSL2/BSL2+ practices. Strong hands-on experience with cell-based assay development, optimization, data analysis, and troubleshooting, including plate-based high-throughput readouts (e.g., luminescence, fluorescence).Excellent verbal, written, and interpersonal communication skills. Desire and capacity to participate in a dynamic and fast-paced research setting. Self-motivation and flexibility, with desire and capacity to work collaboratively as part of a multidisciplinary team. Preferred
Qualifications:
Experience with targeted protein degradation. Experience with cell line engineering strategies (RNAi, CRISPR, lentiviral transduction). Experience with contemporary plasmid cloning techniques. Experience with HTS-enabling technologies (e.g., liquid handlers, compound dispensers).
What we offer:- Industry-competitive compensation
- Annual target bonus
- Stock options 401K plan
- Career advancement opportunities
- Monthly town halls to share business and scientific updates
- Work Hard, Stay Well
- Comprehensive medical, dental, and vision plans for employees and their dependents
- Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution
Employee Assistance Program10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.
Supplemental pay for Pregnancy Disability LeavePaid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care
LifestyleCasual work environment
Volunteer days off each year to spend time contributing to causes you care about
Flexible work schedule
Access to a state-of-the-art gym
Have Fun!
We believe in work/life balance and Fun is at the core of our Core Values. In addition to department and company happy hours, we have regular company-wide and department lunches and social events (ie Padres games, summer picnic, holiday party, bring your kids to work day).
About Us:
Neomorph is a venture backed biotechnology company solving critical problems in human health through the discovery and development of innovative new medicines against 'undruggable targets'. Our team is comprised of industry leading experts in protein degradation and molecular glues who have a track record of ground-breaking discoveries in the field. We are committed to leadership in advancing the science and technology of molecular glue drug discovery, while prosecuting a pipeline of projects through clinical development. Our patient-first, science-driven approach is complemented by our dedication to a supportive and collaborative work environment. Neomorph is headquartered in San Diego, California. Neomorph is committed to pursuing and hiring a diverse workforce and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of any characteristic protected by applicable federal, state or local law. Notice to agencies: Neomorph will not accept unsolicited assistance from recruiting/search agencies for this employment opportunity. Please, no phone calls or emails. All resumes submitted by recruiting or search agencies to any employee at Neomorph via email, the Internet or in any form and/or method without a valid written search/recruitment agreement in place for this position will be deemed the sole property of Neomorph. No fee will be paid in the event the candidate is hired by Neomorph as a result of the referral or through other means.
