Senior Biochemistry & Biophysics Scientist - Degradation

C4 Therapeutics in Watertown, MA, is seeking a Principal Scientist to lead the biochemistry and biophysics team, overseeing assay strategies for hit validation, lead optimization, and mechanism-of-action studies within targeted protein degradation programs. The role combines hands-on lab work with matrixed management across Discovery, Biology, and Chemistry, guiding data interpretation, risk assessments, and program strategy while mentoring scientists and managing CRO collaborations.