Topos BioAt Topos Bio, we're pioneering drug discovery for intrinsically disordered proteins—targets that have eluded conventional approaches in neurodegeneration, oncology, and cardiometabolic disease.
We're seeking a cell biologist to develop and execute cell-based assays for validating computational predictions and supporting medicinal chemistry efforts. You'll work at the interface of disease biology, protein biophysics, and drug screening.
What you will do:
Develop and optimize mammalian cell-based assays for disordered protein targetsExecute phenotypic and reporter-based screening campaigns to validate computational hitsCharacterize compound activity and support structure-activity relationship studiesCollaborate with computational scientists to integrate experimental data with modeling workflowsEstablish robust assay protocols and quality control metricsWhat we are looking forStrong foundation in mammalian cell culture and cellular assay developmentExperience with disease-relevant cellular modelsAbility to troubleshoot complex biological systems and optimize experimental protocolsTrack record of productivity and effective collaborationPreferredPhD in cell and molecular biology with focus on disease modelsIndustry experience in drug discovery or biotechExperience with reporter assays and high-throughput screening platformsFamiliarity with oncology, neurodegeneration, or metabolic disease modelsTrack record of developing novel cellular assays or screening approaches
