Executive Director - Head of Peptide Macrocycles Medicinal Chemistry

Responsibilities: Formulate strategy and execute on the strategy organizing team efforts for deep technical development and to accelerate from target hits through lead optimization towards candidate declaration. Lead the team on and lead (both directionally and operationally) molecule engineering efforts. Inspire people, be an effective team leader, and collaborate in inventing great medicines by removing barriers, committing to high quality scientific hypotheses, and accelerating where possible. Keep safety as a top priority at all times, striving toward a proactive safety culture.

Basic Requirements: PhD in chemistry or synthetic chemistry or peptide chemistry or related field with significant successful drug discovery and development experience. Deep knowledge as well as mastery of the latest developments in oral macrocycles and macrocyclic peptides. Have extensive background and provident track record of work in synthetic chemistry and mRNA display to lead teams to develop oral macrocycle compounds towards lead deceleration and beyond. Understand the challenges and has the ability to plan and lead the team on oral macrocycle lead optimization efforts, can formulate strategy and execute on the strategy organizing team efforts for deep technical development and to accelerate from hits to lead optimization and candidate declaration. Significant knowledge in oral macrocycles, based on library-based screening technologies including at least one of OBOC, solution-phase, AS/MS, mRNA display or related peptide library screening technologies as well as deep understanding of the medicinal chemistry considerations required to advance hits through lead optimization. Proven track record of success with specific programs. Must have demonstrated leadership in development of new medicines, ideally have worked on peptide efforts in both library-based screening technologies and design of strategies for lead optimization. Familiarity with state of the art in computational and structural efforts for lead optimization in macrocyclic peptides is a must. Must have deep scientific expertise and demonstrated ability to lead a team of scientists from within therapeutic/functional areas with a proven track record of delivering candidate molecules into clinical testing. Must have developed molecules from conceptual stage-hit stage all the way to putting them into the clinic and demonstrated track record of success in drug development. Experience and demonstrated success in developing novel drugs, peptides or proteins that have been successful in the clinic is required. Additional Skills/PreferencesGreat understanding of medicinal approach as well as computational and AI/machine learning techniques used for the development and engineering of oral macrocyclic peptide medicines Candidate will understand the whole drug discovery process including lead generation and lead optimization and will partner with cross functional groups including therapeutic areas, ADME, nonclinical safety assessment and PK/PD. Demonstrated deep expertise in drug development with a proven track record of success. Demonstrated ability to make decisions in the midst of ambiguity, seeking appropriate level of information from Protomer leadership and enabling workforce to execute for and contribute to Protomer team’s strategic priorities. Must be an excellent team player, strong attention to detail, strong problem-solving skills, a high level of learning agility, with the ability to lead within a globally matrixed organization and across functions. Open, transparent and able to communicate equally well with employees, team members and cross-functional and/or senior leadership. Team oriented mindset, pleasant to work with and a leader that develops next generation talent as well as delivers results. Ability to think strategically, actively identifying gaps in competencies or capabilities within the organization and taking initiative to drive continuous improvement across Protomer.

Additional Information: Some domestic and international travel is anticipated and expected. Work is on-site and the team is located in Pasadena, California. EEO and Diversity StatementLilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status. Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa Middle East, Central Asia (AMECA) Black Employees at Lilly (BE@Lilly) Chinese Culture Network (CCN) EnAble Evolve Lilly Indian Network (LIN) Organization of Latinx at Lilly (OLA) Pride (LGBTQ+ Allies) Veterans Leadership Network (VLN) Women’s Initiative for Leading at Lilly (WILL)

Compensation and Benefits: Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $168,000 - $290,400. Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). eligibility to participate in a company-sponsored 401(k) pension vacation benefits eligibility for medical, dental, vision and prescription drug benefits flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts) life insurance and death benefits certain time off and leave of absence benefits well‑being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities) Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

Why Join Us: At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people.