Analytical Chemist Position We are looking for an exceptional and rigorous analytical chemist to develop novel methods to characterize the identity, purity, and in vivo biodistribution of oligonucleotide therapeutic candidates. This role spans both analytical and bioanalytical method development, with a focus on LC-MS and HPLC approaches to support oligonucleotide quality assessment, pharmacokinetics (PK), and tissue biodistribution. Experience with oligonucleotide therapeutics is strongly preferred, but exceptional candidates from adjacent analytical chemistry fields willing to rapidly learn oligonucleotide chemistry are encouraged to apply. You will join a growing team of 25 PhD biomedical scientists, chemists, and engineers.
About You:
You have a PhD in Chemistry or a related field and demonstrated expertise in ONE or more of:
Oligonucleotide Analytical Chemistry: Analytical methods for RNA or DNA oligonucleotides (e.g. siRNA, ASOs), including assessments of identity, purity, degradation products, and overall product quality.
Chromatographic Methods: HPLC and related chromatographic methods relevant to oligonucleotide products, including ion-exchange, reversed-phase, SEC, or related approaches for identity, purity, and stability assessment.
Bioanalysis for PK and Biodistribution: LC-MS-based quantitative workflows to enable quantification of oligonucleotides and oligonucleotide conjugates in biological matrices such as plasma, BALF, liver, lung, or other tissues for in vivo PK and biodistribution studies.
Education: PhD (Required)
Experience: 5+ years of relevant R&D experience (including PhD work)
Location: Rockville, MD (onsite)
