Research Scientist - Song Lab

Job Summary: The Song Lab at Massachusetts General Hospital and Harvard Medical School investigates the molecular mechanisms underlying neurodegenerative diseases, including Alzheimer's disease, ALS/FTD, and Huntington's disease. Our research integrates mechanistic neurobiology, human iPSC-derived neuronal models, advanced imaging, proteomics, and emerging AI-enabled technologies to understand how disease-associated proteins disrupt neuronal function and to translate these discoveries into novel biomarkers and therapeutic strategies. The successful candidate will join a highly collaborative and interdisciplinary research environment spanning basic and translational neuroscience, structural biology, and AI-driven protein design. A major focus of this position will be a collaborative project evaluating AI-assisted de novo protein designs targeting pathological forms of amyloid-β, tau, and TDP-43, with the goal of developing new tools for disease detection and therapeutic intervention. Candidates with expertise in one or more of the following areas are particularly encouraged to apply: protein biochemistry, cellular and animal models of neurodegeneration, human tissue processing and analysis, advanced microscopy, and multi-omics approaches. Experience working across disciplines and an interest in translating mechanistic discoveries into biomarkers and therapeutics are highly valued. In consultation with their Principal Investigator (PI), undertake and execute a program of scientific study culminating in publication. Drives research projects scientifically and determines the course of research as evidenced by leadership, obtaining funding, writing, or other recognition. May not necessarily receive independent resources; however, their contribution is essential to the conceptual/scientific success of the project. They assist their PI in the training and supervision of other laboratory personnel and in a wide variety of administrative tasks, as necessary. Does this position require Patient Care? NoEssential Functions-Makes proficient intellectual contributions to scientific strategies of the group/lab and plays a leadership role by acting as subject matter authority in the field. -Contributes to the design and execution of experiments and/or research projects. -Exercises judgment in selecting methods and technologies to obtain results. -May collaborate with external researchers and/or receive external project funding support. -Presents results and prepares publications. -May assist PI in the training and supervision of other staff.

EEO Statement: 1200 The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership "looks like" by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

Location: Charlestown-MA

Type: Full time