Remote Principal Clinical Scientist

Principal Clinical Scientist, ECDAbout the RoleWe are seeking a Principal Clinical Scientist to lead execution of key components of clinical development for our early cancer detection (ECD) program. This role is central to driving study design, clinical data review, and scientific insights across multiple studies. You will serve as a clinical science lead within cross-functional teams – partnering with Clinical Operations, Biostatistics, Medical Affairs, and Regulatory to advance study execution and shape clinical strategy. This is a high-impact role for someone who can operate independently, manage complexity across studies, and influence decision-making at the study and program level. PRIMARY RESPONSIBILITIESLead Clinical Development & Study Design Lead substantial aspects of ECD clinical studies or multiple studiesDrive study design, including objectives, endpoints, eligibility criteria, and schedules of assessmentsAuthor and review protocols, ICFs, CRFs, and study documentsContribute meaningfully to clinical development strategy and study-level decision-makingContribute to process improvements and development of best practicesDrive Data Review & Strategic Insight Lead medical and clinical data review to ensure data quality and integrityAnalyze complex datasets to identify trends, risks, and opportunitiesTranslate data into actionable insights that inform study and program decisionsPartner with safety and medical teams on signal detection and escalationLead Cross-Functional Execution Lead cross-functional study teams and coordinate execution across functionsCollaborate with Clinical Operations, Biostatistics, Medical Affairs, and RegulatoryInfluence decisions and align stakeholders across competing prioritiesRepresent Clinical Science in internal and external forums (e.g., investigators, KOLs) Drive Study Performance & Program Value Oversee enrollment, site performance, and key study metrics across studiesIdentify risks and proactively adjust study-level strategiesPrioritize activities across studies to ensure quality, timelines, and program impactContribute to forecasting, planning, and milestone deliveryAdvance Scientific Communication Lead development of abstracts, presentations, and manuscriptsTranslate clinical and statistical results into clear scientific narrativesSupport internal decision-making and external evidence generationRequired Qualifications Advanced degree (PhD, PharmD, MD, or equivalent; MS/RN with experience considered)8–12 years of experience in clinical research, clinical science, or related fieldStrong experience leading clinical studies and contributing to study designExperience with clinical data review and interpretationPreferred Qualifications Experience in oncology, diagnostics, or early cancer detectionExperience working across multiple studies or programsTrack record of scientific publications and conference presentationsKey Competencies Ability to lead complex clinical studies or multiple workstreams independentlyStrong analytical skills with ability to synthesize complex data into decisionsEffective influencer across functions and senior stakeholdersStrong ownership mindset with ability to prioritize across competing demandsExcellent scientific communication skillsAbility to operate effectively in a fast-paced, ambiguous environmentThe pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations. Remote USA $187,800 - $234,800 USD OUR OPPORTUNITY Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives. The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.