Temp Senior Research Associate/Sr Scientist, Formulation and Delivery Sciences

Hiring Manager: Bret Coldren

Location: Onsite - Carlsbad, CA

Summary: We seek an energetic and detail-oriented Sr. Research Associate or Sr. Scientist to support Ionis's new gene editing franchise. This is an onsite laboratory-based role in nanoparticle formulations R&D for the intracellular delivery of RNA. The successful candidate will synthesize research scale RNA-loaded lipid nanoparticles, perform physical-chemical characterizations, and assist with biological testing in rodents and/or cell culture.

Responsibilities: Meticulous hands-on laboratory work synthesizing and documenting a variety of RNA-loaded lipid nanoparticles using microfluidic mixing, dialysis, filtration, centrifugation, SEC, etc. Perform particle analysis via Ribogreen, DLS, zeta potential, pKa determination, etc and potentially analyze lipids and RNA via HPLC.Assist with routine rodent procedures to dose formulations and assess safety/activity. Thoroughly document results in electronic lab notebooks and assist with analysis of data. Assist in maintaining general laboratory organization and supplies.

Requirements: BS in life sciences, pharmaceutical sciences, chemical engineering, or related discipline with at least 5 yrs of relevant academic/industry laboratory experience (for Sr. RA level) PhD in life sciences, pharmaceutical sciences, chemical engineering, or related discipline with at least 2 years of relevant academic/industry laboratory experience (for Sr. Scientist role).Must have prior expertise in accurately synthesizing numerous bench-scale RNA-containing LNP batches using microfluidic mixing technologies and bench-scale purification. Must have prior experience performing nanoparticle characterization using Ribogreen, DLS, Zeta potential, etc. Experience with analysis of lipids/RNAs via HPLC is a big plus. Ability to learn and perform routine rodent procedures (eg., tail vein injection and necropsy)A team player who can work both independently and with cross-functional teams in a fast-paced, entrepreneurial environment Good organizational and written/verbal communication skills For more information about Ionis and to apply for this position, please visit our website. Reference Requisition # TEMPThe hourly pay scale for this position is $42.34/hour to $75.49/hourNO PHONE CALLS PLEASE. PRINCIPALS ONLY.Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers. Equal Opportunity Employer This employer is required to notify all applicants of their rights pursuant to federal employment laws. For further information, please review the Know Your Rights notice from the Department of Labor.