Title: Oligonucleotide / Peptide Purification Development
Location: Cambridge, MA
Pay: $48.00-$55.00/hr
Schedule: Standard Office Hours
Duration:
6-Month Initial Contract
We are seeking a highly motivated and creative scientist or engineer with process development experience to join anOligonucleotide / Peptide Purification Development team. This position offers the opportunity to develop robust, high-purity purification processes for oligonucleotide and peptide therapeutics and gain hands‑on exposure to the design, development, scale‑up, and transfer of manufacturing processes supporting clinical and commercial programs.
The successful candidate will contribute to the development of novel purification technologies and processes, working across laboratory, pilot‑scale, and manufacturing environments.
Key Responsibilities:
Develop and characterizepurification processes for oligonucleotide and peptide therapeutics, including process development, process characterization, robustness studies, and scale‑up. Support purification unit operations includingchromatography, detritylation, and ultrafiltration/diafiltration (UF/DF) .Utilize multiple chromatography modes and support or learn additional processing steps includingchemical cleavage, conjugation, and hybridization .Investigate novel purification technologies and approaches designed to improvepurity, process robustness, and productivity .Supportearly- and late‑stage process characterizationand robustness studies. Scale up and transfer oligonucleotide purification processes intopilot‑scale and GMP manufacturing facilities .Contribute totechnology transfer activities, manufacturing documentation review, troubleshooting, and on‑the‑manufacturing‑floor support. Supportroot cause investigations and process evaluations, working independently where appropriate with guidance from the supervisor. Collaborate cross‑functionally with teams supportingsynthesis, drug product, analytical development, research, manufacturing, project management, and technology transfer .Document laboratory and development activities throughdevelopment reports and other technical documentation .Lead or supportpilot‑scale activitiesand small, focused technical initiatives. Providetraining and mentoringto new employees as appropriate. Participate in the preparation and authoring ofCMC/regulatory sections for IND submissions .Qualifications Demonstrated experience successfullyplanning and executing scientific projects and experiments .Hands‑on laboratory experience with the purification ofproteins, peptides, and/or DNA/RNA .Experience usingcolumn chromatography, such as: Ion exchange chromatography Hydrophobic interaction chromatography Reversed‑phase chromatography Experience withultrafiltration/diafiltration (UF/DF) .Hands‑on experience analyzing proteins, peptides, and/or DNA/RNA, preferably usingHPLC and UV/Vis spectroscopy .Demonstrated technical proficiency and creativity in developing or evaluatingpurification technologies and approaches .Strong organizational, written, and verbal communication skills. Ability to work effectively bothindependently and within cross‑functional teams .Preferred Qualifications Experience withÄKTA purification systems and UNICORN software .Experience with Design of Experiments (DoE) .Experience withstatistical analysis .Experience with process scale‑up, technology transfer, or GMP manufacturing environments is beneficial.
Education & Experience:
Associate Scientist 3 / Engineer 2Bachelor’s degree inBiochemistry, Chemical Engineering, Chemistry, or a related life science fieldwith2–4 years of industry experience ; orMaster’s degree in a related field with0–2 years of industry experience .Senior Associate Scientist Bachelor’s degree inBiochemistry, Chemical Engineering, Chemistry, or a related life science fieldwith 4+ years of industry experience ; orMaster’s degree in a related field with 2+ years of industry experience .
