Company Description:
We are a privately held, stealth mode start-up biotechnology company developing lipid nanoparticle-based approaches to address unmet medical needs.
The role:
We are seeking an experienced hands-on and strategic Lipid Nanoparticle (LNP) Formulation Scientist to drive the design, execution, and analysis of Design of Experiments (DOE) to establish cutting-edge next-generation LNP platforms focusing on different disease areas. This role will play a critical part in developing, optimizing, and characterizing LNP systems for nucleic acid delivery in a fast-paced, collaborative research environment.
Key responsibilities:- Design, execute, and analyze DOE-based formulation experiments to develop and optimize novel LNP formulations
- Lead formulation innovation efforts, including lipid selection, composition optimization, and novel process development
- Perform LNP screening and characterization, including size, PDI, encapsulation efficiency, stability, and performance metrics
- Lead formulation process scale-up and technology transfer as needed
- Collaborate closely with cross-functional teams (biology, analytics, chemistry, and project management) to advance programs
- Maintain thorough experimental documentation and clearly communicate results and recommendations to stakeholders
- Contribute to troubleshooting formulation challenges and continuously improve experimental workflows
- Professional experience and qualifications
Senior Scientist, PhD in Chemical Engineering, Bioengineering, Pharmaceutical Sciences, Chemistry, Biology, or related field with 3-5 years relevant experience; Principal Scientist or Associate Director, PhD in Chemical Engineering, Bioengineering, Pharmaceutical Sciences, Chemistry, Biology, or related field with 6+ years relevant experience
Strong hands-on experience with LNP formulations, including formulation development and optimization, process development and scaling-upDemonstrated expertise in DOE methodologies and statistical experimental design
Extensive experience with LNP screening and analytical techniques
Deep understanding of lipid-based delivery systems and formulation science principles
Proven ability to work effectively in a team-oriented, fast-paced environment
Strong problem-solving skills and ability to manage multiple priorities simultaneously
Strong communication skills for presenting data and influencing technical decisions
What We Offer:- Opportunity to work at the forefront of LNP formulation innovation
- Collaborative, science-driven culture with high impact research
- Competitive compensation and benefits package, including health, dental, vision, and life insurance 401(k) with company match
