Postdoc: Immunology & Aging Metabolism Research

Department: 866 – Department of Immunology and Immunotherapy

Location: 1470 Madison Ave., 5 th Floor, New York, NY 10029 Department website: https://icahn.mssm.edu/about/departments-offices/immunology-immunotherapy Laboratory website: https://labs.icahn.mssm.edu/meradlab/ https://www.pulestonlab.com/

Responsibilities: The Merad and Puleston Laboratories is seeking highly motivated postdocs to lead projects related to targeting age driven myeloid dysfunction in cancer: unraveling the immunomodulatory and metabolic contributions of GLP1 agonist Goals/Outcome of the research project: This project explores the immune effects of GLP1 receptor agonists (semaglutide and tirzepatide) in aging and disease. Our findings show that GLP1 treatment reduces inflammaging and rescues age-related loss of resident alveolar macrophages with the goal of applying these findings to patients. Using state of the art in vivo stable isotope tracing technology, the incoming candidate will also explore how incretins modulate immune cell metabolism.

Technical Duties: (include any protocols) Perform independent research in mouse model, flow cytometry, scRNA-seq, scATAC-seq technology, confocal microscopy, cell culture and metabolism assays. Critically analyze data quality and results, communicate results to scientists and lay people Write or assist in writing scientific papers and grants Collaborate closely with other scientists to conduct research

Qualifications Qualifications: Ph.D. required Experience working in a research laboratory setting This position is covered by a collective bargaining agreement between the ISMMS and the Sinai Postdoctoral Organizing Committee - UAW. Wages and benefits: See Article 5 and 13 of The collective bargaining agreement found online at https://sinaipostdocunion.org/wp-content/uploads/2023/12/12-17-23-SPOC-UAW-_-Mount-Sinai-Tentative-Agreement-FINAL-PDF.pdf. Our mission at Mount Sinai Health System is to provide compassionate patient care with seamless coordination and to advance medicine through unrivaled education, research, and outreach in the many diverse communities we serve. Mount Sinai Health System is committed to diversity and equal opportunity Employer Description Strength through Unity and Inclusion The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled legacy of achievement, education, and innovation as we work together to transform healthcare. We encourage all team members to actively participate in creating a culture that ensures fair access to opportunities, promotes inclusive practices, and supports the success of every individual. At Mount Sinai, our leaders are committed to fostering a workplace where all employees feel valued, respected, and empowered to grow. We strive to create an environment where collaboration, fairness, and continuous learning drive positive change, improving the well-being of our staff, patients, and organization. Our leaders are expected to challenge outdated practices, promote a culture of respect, and work toward meaningful improvements that enhance patient care and workplace experiences. We are dedicated to building a supportive and welcoming environment where everyone has the opportunity to thrive and advance professionally. Explore this opportunity and be part of the next chapter in our history. About the Mount Sinai Health System: Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. 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New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally. Equal Opportunity Employer The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization. Compensation The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.